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Study of AAV-hSMN1 (Vesemnogene Lantuparvovec) Gene Therapy in Subjects With Progressive Spinal Muscular Atrophy

Recruiting
NCT06288230·Spinal Muscular Atrophy·PHASE1

Compensation

Compensation not confirmed

Sponsor

Lantu Biopharma

Sites

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Enrollment

20 participants

Remote Eligible
Self-Employed Friendly

This is an interventional study to evaluate safety and efficacy of AAV-hSMN1 in spinal muscular atrophy patients.

App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)Therapy

Recruiting
NCT06367257·Squamous Cell Carcinoma of Head and Neck·NA

Compensation

Compensation not confirmed

Sponsor

University of Erlangen-Nürnberg Medical School

Sites

See website

Enrollment

148 participants

Patients with head and neck cancer requiring definitive or adjuvant radio(chemo)therapy can take part in the study. The aim is to record the nutritional status and diet of the patients during the trial and regularly at a period of 8 weeks after irradiation and to reduce the rate of weight loss and malnutrition.

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Clinical Trial Study

Recruiting
NCT00000000·Condition·NA

Compensation

Compensation not confirmed

Sponsor

Research Organization

Sites

See website

Enrollment

60 participants

Remote Eligible
Self-Employed Friendly

Insomnia is defined as the inability to fall asleep or stay asleep at night and it is one of the most prevalent sleep disorders that can have deleterious impacts on health and this population's quality of life. Currently, both pharmaceutical interventions (trazodone) and cognitive behavioral therapy (CBTi) are widely used to treat patients with insomnia. Although CBTi has been efficacious in many patients, multitude of barriers for receiving treatment such as its limited availability of therapists, high costs and long wait times challenge its ability in sufficiently meeting the population's health needs and demands. To improve the delivery of CBT, electronically delivered CBTi (e-CBTi) has been developed as an accessible and effective alternative intervention for improving sleep outcomes in patients with insomnia. While evidence suggest that e-CBTi is effective when compared to placebos/waitlist control, evidence comparing guided e-CBTi to pharmaceutical interventions is still insufficient and needs further exploration.

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